6IHI

Crystal structure of RasADH 3B3/I91V from Ralstonia.sp in complex with NADPH and A6O

Summary for 6IHI

• Entry DOI: 10.2210/pdb6ihi/pdb
• Descriptor: Alclohol dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2R,3S)-2-ethyl-2-[(2E)-2-(6-methoxy-3,4-dihydro-2H-naphthalen-1-ylidene)ethyl]-3-oxidanyl-cyclopentan-1-one, ... (4 entities in total)
• Functional Keywords: oxidoreductase, kred, biocatalyst, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Ralstonia sp.
• Total number of polymer chains: 4
• Total formula weight: 109439.71

Authors

Zhang, H.L.,Chen, X.,Liu, W.D.,Wu, Q.Q.,Zhu, D.M. (deposition date: 2018-09-30, release date: 2019-10-02, Last modification date: 2023-11-22)

• Primary citation: Chen, X.,Zhang, H.L.,Ma, M.S.,Liu, W.,Li, J.,Feng, J.,Liu, X.,Osuna, S.,Guo, R.T.,Wu, Q.,Zhu, D.,Ma, Y.; Efficient reductive desymmetrization of bulky 1,3-cyclodiketones enabled by structure-guided directed evolution of a carbonyl reductase.; Nat Catal, 2:931-941, 2019; DOI: 10.1038/s41929-019-0347-y

Experimental method

X-RAY DIFFRACTION (1.78 Å)