6IHH

Crystal structure of RasADH F12 from Ralstonia.sp in complex with NADPH and A6O

6IHH の概要

• エントリーDOI: 10.2210/pdb6ihh/pdb
• 分子名称: Alclohol dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2R,3S)-2-ethyl-2-[(2E)-2-(6-methoxy-3,4-dihydro-2H-naphthalen-1-ylidene)ethyl]-3-oxidanyl-cyclopentan-1-one, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, kred, biocatalyst, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Ralstonia sp.
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 55063.50

構造登録者

Zhang, H.L.,Chen, X.,Liu, W.D.,Wu, Q.Q.,Zhu, D.M. (登録日: 2018-09-30, 公開日: 2019-10-02, 最終更新日: 2023-11-22)

• 主引用文献: Chen, X.,Zhang, H.,Ma, M.S.,Liu, W.,Li, J.,Feng, J.,Liu, X.,Osuna, S.,Guo, R.T.,Wu, Q.,Zhu, D.,Ma, Y.; Efficient reductive desymmetrization of bulky 1,3-cyclodiketones enabled by structure-guided directed evolution of a carbonyl reductase.; Nat Catal, 2:931-941, 2019; DOI: 10.1038/s41929-019-0347-y

実験手法

X-RAY DIFFRACTION (1.8 Å)