6IH7

Crystal structure of a standalone versatile EAL protein from Vibrio cholerae O395 - 3',3'-cGAMP bound form

6IH7 の概要

• エントリーDOI: 10.2210/pdb6ih7/pdb
• 分子名称: cyclic di nucleotide phoshodiesterase, 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: cyclic dinucleotide phosphodiesterase, nucleotide binding, hydrolase
• 由来する生物種: Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 59559.31

構造登録者

Yadav, M.,Pal, K.,Sen, U. (登録日: 2018-09-28, 公開日: 2019-10-02, 最終更新日: 2023-11-22)

• 主引用文献: Yadav, M.,Pal, K.,Sen, U.; Structures of c-di-GMP/cGAMP degrading phosphodiesterase VcEAL: identification of a novel conformational switch and its implication.; Biochem.J., 476:3333-3353, 2019; PubMed: 31647518; DOI: 10.1042/BCJ20190399

実験手法

X-RAY DIFFRACTION (2.25 Å)