Crystal Structure of HIV-1 Env ConM SOSIP.v7 in Complex with bNAb PGT124 and 35O22

Summary for 6IEQ

DescriptorEnvelope glycoprotein gp160, PGT124 Fab Light Chain, PGT124 Fab Heavy Chain, ... (9 entities in total)
Functional Keywordshiv-1, envelop protein, consensus sequence-based conm sosip, broadly neutralizing antibody, viral protein
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains6
Total molecular weight181119.89
Han, B.W.,Wilson, I.A. (deposition date: 2018-09-16, release date: 2019-05-22, Last modification date: 2019-06-12)
Primary citation
Sliepen, K.,Han, B.W.,Bontjer, I.,Mooij, P.,Garces, F.,Behrens, A.J.,Rantalainen, K.,Kumar, S.,Sarkar, A.,Brouwer, P.J.M.,Hua, Y.,Tolazzi, M.,Schermer, E.,Torres, J.L.,Ozorowski, G.,van der Woude, P.,de la Pena, A.T.,van Breemen, M.J.,Camacho-Sanchez, J.M.,Burger, J.A.,Medina-Ramirez, M.,Gonzalez, N.,Alcami, J.,LaBranche, C.,Scarlatti, G.,van Gils, M.J.,Crispin, M.,Montefiori, D.C.,Ward, A.B.,Koopman, G.,Moore, J.P.,Shattock, R.J.,Bogers, W.M.,Wilson, I.A.,Sanders, R.W.
Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence.
Nat Commun, 10:2355-2355, 2019
PubMed: 31142746 (PDB entries with the same primary citation)
DOI: 10.1038/s41467-019-10262-5
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2942 0.1% 0.4% 4.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution