6IC5

Human cathepsin-C in complex with dipeptidyl cyclopropyl nitrile inhibitor 2

6IC5 の概要

• エントリーDOI: 10.2210/pdb6ic5/pdb
• 分子名称: Dipeptidyl peptidase 1, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: cathepsin-c, cysteine protease, structure-based drug design, arthritis, hydrolase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 41326.63

構造登録者

Hakansson, M.,Logan, D.T.,Korkmaz, B.,Lesner, A.,Wysocka, M.,Gieldon, A.,Gauthier, F.,Jenne, D.,Lauritzen, C.,Pedersen, J. (登録日: 2018-12-02, 公開日: 2019-04-24, 最終更新日: 2020-07-29)

• 主引用文献: Korkmaz, B.,Lesner, A.,Wysocka, M.,Gieldon, A.,Hakansson, M.,Gauthier, F.,Logan, D.T.,Jenne, D.E.,Lauritzen, C.,Pedersen, J.; Structure-based design and in vivo anti-arthritic activity evaluation of a potent dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C.; Biochem. Pharmacol., 164:349-367, 2019; PubMed: 30978322; DOI: 10.1016/j.bcp.2019.04.006

実験手法

X-RAY DIFFRACTION (2 Å)