6IBO

Catalytic deficiency of O-GlcNAc transferase leads to X-linked intellectual disability

Summary for 6IBO

• Entry DOI: 10.2210/pdb6ibo/pdb
• Descriptor: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, ALA-VAL-SER-ARG-ALA, (2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, ... (5 entities in total)
• Functional Keywords: transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 82735.09

Authors

Gundogdu, M.,van Aalten, D.M.F. (deposition date: 2018-11-30, release date: 2019-07-24, Last modification date: 2024-01-24)

• Primary citation: Pravata, V.M.,Muha, V.,Gundogdu, M.,Ferenbach, A.T.,Kakade, P.S.,Vandadi, V.,Wilmes, A.C.,Borodkin, V.S.,Joss, S.,Stavridis, M.P.,van Aalten, D.M.F.; Catalytic deficiency of O-GlcNAc transferase leads to X-linked intellectual disability.; Proc.Natl.Acad.Sci.USA, 116:14961-14970, 2019; PubMed: 31296563; DOI: 10.1073/pnas.1900065116

Experimental method

X-RAY DIFFRACTION (2.17 Å)