6IAS
structure of human NKp46 in complex with antibody NKp46-1 and NKp46-4
Summary for 6IAS
Entry DOI | 10.2210/pdb6ias/pdb |
Descriptor | Fab NKp46-1 heavy chain, Fab NKp46-1 light chain (3 entities in total) |
Functional Keywords | therapeutic antibody, immune system |
Biological source | synthetic construct More |
Total number of polymer chains | 2 |
Total formula weight | 46478.77 |
Authors | Roussel, A.,Amigues, B. (deposition date: 2018-11-27, release date: 2019-06-12, Last modification date: 2019-06-26) |
Primary citation | Gauthier, L.,Morel, A.,Anceriz, N.,Rossi, B.,Blanchard-Alvarez, A.,Grondin, G.,Trichard, S.,Cesari, C.,Sapet, M.,Bosco, F.,Rispaud-Blanc, H.,Guillot, F.,Cornen, S.,Roussel, A.,Amigues, B.,Habif, G.,Caraguel, F.,Arrufat, S.,Remark, R.,Romagne, F.,Morel, Y.,Narni-Mancinelli, E.,Vivier, E. Multifunctional Natural Killer Cell Engagers Targeting NKp46 Trigger Protective Tumor Immunity. Cell, 177:1701-1713.e16, 2019 Cited by PubMed: 31155232DOI: 10.1016/j.cell.2019.04.041 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
Download full validation report