6I9L

JmjC domain-containing protein 5 (JMJD5) in complex with Mn and pyridine-2,4-dicarboxylic acid (2,4-PDCA)

6I9L の概要

• エントリーDOI: 10.2210/pdb6i9l/pdb
• 分子名称: JmjC domain-containing protein 5, MANGANESE (II) ION, PYRIDINE-2,4-DICARBOXYLIC ACID, ... (5 entities in total)
• 機能のキーワード: oxidoreductase, non-heme, iron, 2-oxoglutarate, dioxygenase, jmjc, jmjc domain, lysine-specific demethylase 8, jmjc domain-containing protein 5, arginyl c-3 hydroxylase, jmjd5, kdm8, oxygenase, hypoxia, dna-binding, metal-binding, translation, dsbh, facial triad, cytoplasm, jmjc hydroxylase, jmjc demethylase, kdms, post-translational modifications, ptm, beta-hydroxylation, hydroxylation, arginine hydroxylation, rcc1 domain-containing protein 1, rccd1, regulator of chromosome condensation, 40s ribosomal protein s6, rps6, ribosome biogenesis, transcription, epigenetic regulation, signaling, development, cell structure, transcription activator/inhibitor, phosphorylation, cancer, polymorphism
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30077.75

構造登録者

Chowdhury, R.,Islam, M.S.,Schofield, C.J. (登録日: 2018-11-23, 公開日: 2019-12-04, 最終更新日: 2024-01-31)

• 主引用文献: Islam, M.S.,Markoulides, M.,Chowdhury, R.,Schofield, C.J.; Structural analysis of the 2-oxoglutarate binding site of the circadian rhythm linked oxygenase JMJD5.; Sci Rep, 12:20680-20680, 2022; PubMed: 36450832; DOI: 10.1038/s41598-022-24154-0

実験手法

X-RAY DIFFRACTION (1.53 Å)