6I99

Bone Marrow Tyrosine Kinase in Chromosome X in complex with a newly designed covalent inhibitor JS24

6I99 の概要

• エントリーDOI: 10.2210/pdb6i99/pdb
• 分子名称: Cytoplasmic tyrosine-protein kinase BMX, ~{N}-[2-methyl-5-[8-[4-(methylsulfonylamino)phenyl]-2-oxidanylidene-benzo[h][1,6]naphthyridin-1-yl]phenyl]-3-oxidanyl-propanamide (3 entities in total)
• 機能のキーワード: cytoplasmic tyrosine-kinase bmx, homo sapiens, cytosolic protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 66214.04

構造登録者

Sousa, B.B.,Matias, P.M.,Marques, M.C.,Seixas, J.D.,Bernardes, G.J.L. (登録日: 2018-11-22, 公開日: 2020-05-27, 最終更新日: 2024-01-24)

• 主引用文献: Seixas, J.D.,Sousa, B.B.,Marques, M.C.,Guerreiro, A.,Traquete, R.,Rodrigues, T.,Albuquerque, I.S.,Sousa, M.F.Q.,Lemos, A.R.,Sousa, P.M.F.,Bandeiras, T.M.,Wu, D.,Doyle, S.K.,Robinson, C.V.,Koehler, A.N.,Corzana, F.,Matias, P.M.,Bernardes, G.J.L.; Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors; Chem.Biol., 2020; DOI: 10.1039/D0CB00033G

実験手法

X-RAY DIFFRACTION (2.001 Å)