6I8T
THE CATALYTIC FRAGMENT OF POLY(ADP-RIBOSE) POLYMERASE COMPLEXED WITH AN ISOINDOLINONE INHIBITOR
Summary for 6I8T
Entry DOI | 10.2210/pdb6i8t/pdb |
Descriptor | Poly [ADP-ribose] polymerase 1, (1~{R})-2-(1-cyclohexylpiperidin-4-yl)-1-methyl-3-oxidanylidene-1~{H}-isoindole-4-carboxamide (3 entities in total) |
Functional Keywords | transferase, chicken parp1, inhibitor complex, adp-ribosylation, dna damage |
Biological source | Gallus gallus (Chicken) |
Total number of polymer chains | 1 |
Total formula weight | 40983.10 |
Authors | Casale, E.,Papeo, G.,Montagnoli, A. (deposition date: 2018-11-21, release date: 2019-05-01, Last modification date: 2024-05-15) |
Primary citation | Papeo, G.,Orsini, P.,Avanzi, N.R.,Borghi, D.,Casale, E.,Ciomei, M.,Cirla, A.,Desperati, V.,Donati, D.,Felder, E.R.,Galvani, A.,Guanci, M.,Isacchi, A.,Posteri, H.,Rainoldi, S.,Riccardi-Sirtori, F.,Scolaro, A.,Montagnoli, A. Discovery of Stereospecific PARP-1 Inhibitor Isoindolinone NMS-P515. Acs Med.Chem.Lett., 10:534-538, 2019 Cited by PubMed: 30996792DOI: 10.1021/acsmedchemlett.8b00569 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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