6I8A
The crystal structure of the Pol2 catalytic domain of DNA polymerase epsilon carrying a P301R substitution.
Summary for 6I8A
| Entry DOI | 10.2210/pdb6i8a/pdb |
| Related | 6fwk 6g0a |
| Descriptor | DNA polymerase epsilon catalytic subunit A, Primer DNA, Template DNA, ... (7 entities in total) |
| Functional Keywords | dna, pol2, p301r, p286r, cancer, endometrial, dna binding protein, pol epsilon |
| Biological source | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) More |
| Total number of polymer chains | 6 |
| Total formula weight | 291888.19 |
| Authors | Parkash, V.,Johansson, E. (deposition date: 2018-11-19, release date: 2019-01-30, Last modification date: 2024-01-24) |
| Primary citation | Parkash, V.,Kulkarni, Y.,Ter Beek, J.,Shcherbakova, P.V.,Kamerlin, S.C.L.,Johansson, E. Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon. Nat Commun, 10:373-373, 2019 Cited by PubMed: 30670696DOI: 10.1038/s41467-018-08114-9 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.652 Å) |
Structure validation
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