6I74

Galectin-3C in complex with substituted polyfluoroaryl monothiogalactoside derivative 1

6I74 の概要

• エントリーDOI: 10.2210/pdb6i74/pdb
• 分子名称: Galectin-3, (2~{R},3~{R},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-(4-methylphenyl)sulfanyl-4-[4-[2,3,4,5,6-pentakis(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxane-3,5-diol (3 entities in total)
• 機能のキーワード: lectin, carbohydrate-binding protein, galactose-specific lectin 3, galactoside-binding protein, galbp, ige-6 binding protein, l-31, laminin-binding protein, lectin l-29, mac-2, sugar binding protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16204.49

構造登録者

Kumar, R.,Peterson, K.,Nilsson, U.J.,Logan, D.T. (登録日: 2018-11-15, 公開日: 2019-01-23, 最終更新日: 2024-01-24)

• 主引用文献: Kumar, R.,Peterson, K.,Misini Ignjatovic, M.,Leffler, H.,Ryde, U.,Nilsson, U.J.,Logan, D.T.; Substituted polyfluoroaryl interactions with an arginine side chain in galectin-3 are governed by steric-, desolvation and electronic conjugation effects.; Org. Biomol. Chem., 17:1081-1089, 2019; PubMed: 30632578; DOI: 10.1039/c8ob02888e

実験手法

X-RAY DIFFRACTION (0.959 Å)