6I4N

Dodecamer DNA containing the synthetic base pair P-Z in complex with a pyrrole-imidazole polyamide

Summary for 6I4N

DescriptorDNA (5'-D(*CP*GP*AP*TP*(DP)P*TP*AP*(DZ)P*AP*TP*CP*G)-3'), 3-[3-[[4-[[4-[[4-[[4-[[(2~{R})-2-azaniumyl-4-[[1-methyl-4-[[1-methyl-4-[[1-methyl-4-[(1-methylimidazol-2-yl)carbonylamino]pyrrol-2-yl]carbonylamino]pyrrol-2-yl]carbonylamino]pyrrol-2-yl]carbonylamino]butanoyl]amino]-1-methyl-imidazol-2-yl]carbonylamino]-1-methyl-pyrrol-2-yl]carbonylamino]-1-methyl-pyrrol-2-yl]carbonylamino]-1-methyl-pyrrol-2-yl]carbonylamino]propanoylamino]propyl-dimethyl-azanium (2 entities in total)
Functional Keywordsdna, synthetic base pair, z, p, pyrrole-imidazole polyamide
Biological sourcesynthetic construct
Total number of polymer chains2
Total molecular weight8652.18
Authors
Padroni, G.,Parkison, J.,Burley, G.A. (deposition date: 2018-11-10, release date: 2019-06-12)
Primary citation
Padroni, G.,Withers, J.M.,Taladriz-Sender, A.,Reichenbach, L.F.,Parkinson, J.A.,Burley, G.A.
Sequence-selective minor groove recognition of a DNA duplex containing synthetic genetic components.
J.Am.Chem.Soc., 2019
PubMed: 31117639 (PDB entries with the same primary citation)
DOI: 10.1021/jacs.8b12444
MImport into Mendeley
Experimental method
SOLUTION NMR
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Structure validation

Clashscore0MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures