Crystal structure of the Mycobacterium tuberculosis PknB kinase domain (L33E mutant) in complex with its substrate GarA

Summary for 6I2P

DescriptorSerine/threonine-protein kinase PknB, Glycogen accumulation regulator GarA, UNK-UNK-UNK-UNK-UNK, ... (7 entities in total)
Functional Keywordskinase, fha-domain protein, signaling protein
Biological sourceMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains5
Total molecular weight97476.74
Andre-Leroux, G.,Hindie, V.,Barilone, N.,Bellinzoni, M.,Alzari, P.M. (deposition date: 2018-11-01, release date: 2019-05-22)
Primary citation
Wagner, T.,Andre-Leroux, G.,Hindie, V.,Barilone, N.,Lisa, M.N.,Hoos, S.,Raynal, B.,Vulliez-Le Normand, B.,O'Hare, H.M.,Bellinzoni, M.,Alzari, P.M.
Structural insights into the functional versatility of an FHA domain protein in mycobacterial signaling.
Sci.Signal., 12:-, 2019
PubMed: 31064884 (PDB entries with the same primary citation)
DOI: 10.1126/scisignal.aav9504
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2392 0.1% 1.2% 3.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution