6I2P

Crystal structure of the Mycobacterium tuberculosis PknB kinase domain (L33E mutant) in complex with its substrate GarA

Summary for 6I2P

Entry DOI	10.2210/pdb6i2p/pdb
Descriptor	Serine/threonine-protein kinase PknB, Glycogen accumulation regulator GarA, UNK-UNK-UNK-UNK-UNK, ... (7 entities in total)
Functional Keywords	kinase, fha-domain protein, signaling protein
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) More
Total number of polymer chains	5
Total formula weight	97476.74
Authors	Andre-Leroux, G.,Hindie, V.,Barilone, N.,Bellinzoni, M.,Alzari, P.M. (deposition date: 2018-11-01, release date: 2019-05-22, Last modification date: 2024-01-24)
Primary citation	Wagner, T.,Andre-Leroux, G.,Hindie, V.,Barilone, N.,Lisa, M.N.,Hoos, S.,Raynal, B.,Vulliez-Le Normand, B.,O'Hare, H.M.,Bellinzoni, M.,Alzari, P.M. Structural insights into the functional versatility of an FHA domain protein in mycobacterial signaling. Sci.Signal., 12:-, 2019 Cited by PubMed: 31064884 DOI: 10.1126/scisignal.aav9504 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.37 Å)

Structure validation