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6I0P

Structure of quinolinate synthase in complex with 6-mercaptopyridine-2,3-dicarboxylic acid

Summary for 6I0P
Entry DOI10.2210/pdb6i0p/pdb
Related6I0K
DescriptorQuinolinate synthase A, IRON/SULFUR CLUSTER, 6-mercaptopyridine-2,3-dicarboxylic acid, ... (6 entities in total)
Functional Keywordsnad biosynthesis, iron sulfur cluster, transferase
Biological sourceThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Total number of polymer chains1
Total formula weight35321.85
Authors
Volbeda, A.,Fontecilla-Camps, J.C. (deposition date: 2018-10-26, release date: 2019-03-20, Last modification date: 2024-01-24)
Primary citationSaez Cabodevilla, J.,Volbeda, A.,Hamelin, O.,Latour, J.M.,Gigarel, O.,Clemancey, M.,Darnault, C.,Reichmann, D.,Amara, P.,Fontecilla-Camps, J.C.,Ollagnier de Choudens, S.
Design of specific inhibitors of quinolinate synthase based on [4Fe-4S] cluster coordination.
Chem.Commun.(Camb.), 55:3725-3728, 2019
Cited by
PubMed Abstract: Quinolinate synthase (NadA) is a [4Fe-4S] cluster-containing enzyme involved in the formation of quinolinic acid, the precursor of the essential NAD coenzyme. Here, we report the synthesis and activity of derivatives of the first inhibitor of NadA. Using multidisciplinary approaches we have investigated their action mechanism and discovered additional specific inhibitors of this enzyme.
PubMed: 30855610
DOI: 10.1039/c8cc09023h
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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