6I07
Crystal structure of EpCAM in complex with scFv
Summary for 6I07
Entry DOI | 10.2210/pdb6i07/pdb |
Descriptor | Single chain Fv, Epithelial cell adhesion molecule, GLYCEROL, ... (4 entities in total) |
Functional Keywords | immune system, single chain fv, scfv, epcam |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 113052.58 |
Authors | Casaletto, J.B.,Geddie, M.L.,Abu-Yousif, A.O.,Masson, K.,Fulgham, A.,Boudot, A.,Maiwald, T.,Kearns, J.D.,Kohli, N.,Su, S.,Razlog, M.,Raue, A.,Kalra, A.,Hakansson, M.,Logan, D.T.,Welin, M.,Chattopadhyay, S.,Harms, B.D.,Nielsen, U.B.,Schoeberl, B.,Lugovskoy, A.A.,MacBeath, G. (deposition date: 2018-10-25, release date: 2019-03-13, Last modification date: 2024-01-24) |
Primary citation | Casaletto, J.B.,Geddie, M.L.,Abu-Yousif, A.O.,Masson, K.,Fulgham, A.,Boudot, A.,Maiwald, T.,Kearns, J.D.,Kohli, N.,Su, S.,Razlog, M.,Raue, A.,Kalra, A.,Hakansson, M.,Logan, D.T.,Welin, M.,Chattopadhyay, S.,Harms, B.D.,Nielsen, U.B.,Schoeberl, B.,Lugovskoy, A.A.,MacBeath, G. MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM. Proc.Natl.Acad.Sci.USA, 116:7533-7542, 2019 Cited by PubMed: 30898885DOI: 10.1073/pnas.1819085116 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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