6HZM
Cryo-EM structure of the ABCG2 E211Q mutant bound to ATP and Magnesium (alternative placement of Magnesium into the cryo-EM density)
Summary for 6HZM
Entry DOI | 10.2210/pdb6hzm/pdb |
Related | 6HBU |
EMDB information | 0190 |
Descriptor | ATP-binding cassette sub-family G member 2, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | multidrug transporter, membrane protein, cancer |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 145832.71 |
Authors | Manolaridis, I.,Jackson, S.M.,Taylor, N.M.I.,Kowal, J.,Stahlberg, H.,Locher, K.P. (deposition date: 2018-10-23, release date: 2018-11-14, Last modification date: 2019-12-18) |
Primary citation | Manolaridis, I.,Jackson, S.M.,Taylor, N.M.I.,Kowal, J.,Stahlberg, H.,Locher, K.P. Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states. Nature, 563:426-430, 2018 Cited by PubMed: 30405239DOI: 10.1038/s41586-018-0680-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.09 Å) |
Structure validation
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