6HWU
Crystal structure of p38alpha in complex with a photoswitchable 2-Azothiazol-based Inhibitor (compound 2)
Summary for 6HWU
Entry DOI | 10.2210/pdb6hwu/pdb |
Descriptor | Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside, 3-(2,5-dimethoxyphenyl)-~{N}-[4-[4-(4-fluorophenyl)-2-[(~{E})-phenyldiazenyl]-1,3-thiazol-5-yl]pyridin-2-yl]propanamide, ... (4 entities in total) |
Functional Keywords | p38alpha, mapk14, photoswitchable, azothiazol, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 42939.02 |
Authors | Mueller, M.P.,Rauh, D. (deposition date: 2018-10-15, release date: 2019-04-17, Last modification date: 2024-01-24) |
Primary citation | Schehr, M.,Ianes, C.,Weisner, J.,Heintze, L.,Muller, M.P.,Pichlo, C.,Charl, J.,Brunstein, E.,Ewert, J.,Lehr, M.,Baumann, U.,Rauh, D.,Knippschild, U.,Peifer, C.,Herges, R. 2-Azo-, 2-diazocine-thiazols and 2-azo-imidazoles as photoswitchable kinase inhibitors: limitations and pitfalls of the photoswitchable inhibitor approach. Photochem. Photobiol. Sci., 18:1398-1407, 2019 Cited by PubMed: 30924488DOI: 10.1039/c9pp00010k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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