6HVE

Kinase domain of cSrc in complex with compound 9

6HVE の概要

• エントリーDOI: 10.2210/pdb6hve/pdb
• 分子名称: Proto-oncogene tyrosine-protein kinase Src, ~{N}-[3-(4-methoxy-7~{H}-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]prop-2-enamide (3 entities in total)
• 機能のキーワード: kinase inhibitor covalent inhibitor, transferase
• 由来する生物種: Gallus gallus (Chicken)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 66134.22

構造登録者

Keul, M.,Mueller, M.P.,Rauh, D. (登録日: 2018-10-10, 公開日: 2019-10-23, 最終更新日: 2020-01-01)

• 主引用文献: Lategahn, J.,Keul, M.,Klovekorn, P.,Tumbrink, H.L.,Niggenaber, J.,Muller, M.P.,Hodson, L.,Flasshoff, M.,Hardick, J.,Grabe, T.,Engel, J.,Schultz-Fademrecht, C.,Baumann, M.,Ketzer, J.,Muhlenberg, T.,Hiller, W.,Gunther, G.,Unger, A.,Muller, H.,Heimsoeth, A.,Golz, C.,Blank-Landeshammer, B.,Kollipara, L.,Zahedi, R.P.,Strohmann, C.,Hengstler, J.G.,van Otterlo, W.A.L.,Bauer, S.,Rauh, D.; Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S.; Chem Sci, 10:10789-10801, 2019; PubMed: 31857889; DOI: 10.1039/c9sc03445e

実験手法

X-RAY DIFFRACTION (1.9 Å)