6HSV

Engineered higher-order assembly of Cholera Toxin B subunits via the addition of C-terminal parallel coiled-coiled domains

Summary for 6HSV

Entry DOI	10.2210/pdb6hsv/pdb
Descriptor	Toxin B subunit, PHOSPHATE ION, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (5 entities in total)
Functional Keywords	cholera toxin b, ctb, parallel coiled coils, higher order assembly, self assembly, designed protein, nanotube, toxin
Biological source	Vibrio cholerae
Total number of polymer chains	20
Total formula weight	281394.02
Authors	Pearson, A.R.,Turnbull, W.B.,Ross, J.F.,Trinh, C.H.,Webb, M.E. (deposition date: 2018-10-01, release date: 2019-03-20, Last modification date: 2024-01-24)
Primary citation	Ross, J.F.,Wildsmith, G.C.,Johnson, M.,Hurdiss, D.L.,Hollingsworth, K.,Thompson, R.F.,Mosayebi, M.,Trinh, C.H.,Paci, E.,Pearson, A.R.,Webb, M.E.,Turnbull, W.B. Directed Assembly of Homopentameric Cholera Toxin B-Subunit Proteins into Higher-Order Structures Using Coiled-Coil Appendages. J.Am.Chem.Soc., 141:5211-5219, 2019 Cited by PubMed: 30856321 DOI: 10.1021/jacs.8b11480 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation