6HQ0

Crystal structure of ENL (MLLT1), apo form

Summary for 6HQ0

Entry DOI	10.2210/pdb6hq0/pdb
Related	6HPW 6HPX 6HPY 6HPZ
Descriptor	Protein ENL, 1,2-ETHANEDIOL (3 entities in total)
Functional Keywords	yeats domain, inhibitor complex, structural genomics, structural genomics consortium, sgc, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	18622.42
Authors	Heidenreich, D.,Chaikuad, A.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2018-09-22, release date: 2018-11-28, Last modification date: 2024-01-24)
Primary citation	Heidenreich, D.,Moustakim, M.,Schmidt, J.,Merk, D.,Brennan, P.E.,Fedorov, O.,Chaikuad, A.,Knapp, S. Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL). J.Med.Chem., 61:10929-10934, 2018 Cited by PubMed: 30407816 DOI: 10.1021/acs.jmedchem.8b01457 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.81 Å)

Structure validation