6HPJ
Structure of human SRSF1 RRM1 bound to AACAAA RNA
Summary for 6HPJ
Entry DOI | 10.2210/pdb6hpj/pdb |
NMR Information | BMRB: 34317 |
Descriptor | Immunoglobulin G-binding protein G,Serine/arginine-rich splicing factor 1, RNA (5'-R(*AP*AP*CP*AP*AP*A)-3') (2 entities in total) |
Functional Keywords | splicing, sr protein, srsf1, rrm, spinal muscular atrophy, sma, rna, rna binding protein |
Biological source | Streptococcus sp. group G More |
Total number of polymer chains | 2 |
Total formula weight | 19862.95 |
Authors | Allain, F.T.H.,Clery, A. (deposition date: 2018-09-21, release date: 2020-11-18, Last modification date: 2024-05-15) |
Primary citation | Clery, A.,Krepl, M.,Nguyen, C.K.X.,Moursy, A.,Jorjani, H.,Katsantoni, M.,Okoniewski, M.,Mittal, N.,Zavolan, M.,Sponer, J.,Allain, F.H. Structure of SRSF1 RRM1 bound to RNA reveals an unexpected bimodal mode of interaction and explains its involvement in SMN1 exon7 splicing. Nat Commun, 12:428-428, 2021 Cited by PubMed: 33462199DOI: 10.1038/s41467-020-20481-w PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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