6HP9

Structure of the kinase domain of human DDR1 in complex with a 2-Amino-2,3-Dihydro-1H-Indene-5-Carboxamide-based inhibitor

Summary for 6HP9

Entry DOI	10.2210/pdb6hp9/pdb
Descriptor	Epithelial discoidin domain-containing receptor 1, (2~{R})-~{N}-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-2-(pyrimidin-5-ylamino)-2,3-dihydro-1~{H}-indene-5-carboxamide (3 entities in total)
Functional Keywords	ddr1, structural genomics, structural genomics consortium, sgc, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	72465.13
Authors	Pinkas, D.M.,Fox, A.E.,Kupinska, K.,Burgess-Brown, N.A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.N.,Structural Genomics Consortium (SGC) (deposition date: 2018-09-19, release date: 2019-01-30, Last modification date: 2024-01-24)
Primary citation	Zhu, D.,Huang, H.,Pinkas, D.M.,Luo, J.,Ganguly, D.,Fox, A.E.,Arner, E.,Xiang, Q.,Tu, Z.C.,Bullock, A.N.,Brekken, R.A.,Ding, K.,Lu, X. 2-Amino-2,3-dihydro-1H-indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer Efficacy. J.Med.Chem., 62:7431-7444, 2019 Cited by PubMed: 31310125 DOI: 10.1021/acs.jmedchem.9b00365 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.96 Å)

Structure validation