6HP9

Structure of the kinase domain of human DDR1 in complex with a 2-Amino-2,3-Dihydro-1H-Indene-5-Carboxamide-based inhibitor

6HP9 の概要

• エントリーDOI: 10.2210/pdb6hp9/pdb
• 分子名称: Epithelial discoidin domain-containing receptor 1, (2~{R})-~{N}-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-2-(pyrimidin-5-ylamino)-2,3-dihydro-1~{H}-indene-5-carboxamide (3 entities in total)
• 機能のキーワード: ddr1, structural genomics, structural genomics consortium, sgc, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72465.13

構造登録者

Pinkas, D.M.,Fox, A.E.,Kupinska, K.,Burgess-Brown, N.A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.N.,Structural Genomics Consortium (SGC) (登録日: 2018-09-19, 公開日: 2019-01-30, 最終更新日: 2024-01-24)

• 主引用文献: Zhu, D.,Huang, H.,Pinkas, D.M.,Luo, J.,Ganguly, D.,Fox, A.E.,Arner, E.,Xiang, Q.,Tu, Z.C.,Bullock, A.N.,Brekken, R.A.,Ding, K.,Lu, X.; 2-Amino-2,3-dihydro-1H-indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer Efficacy.; J.Med.Chem., 62:7431-7444, 2019; PubMed: 31310125; DOI: 10.1021/acs.jmedchem.9b00365

実験手法

X-RAY DIFFRACTION (1.96 Å)