6HOW

Trypanosoma brucei PTR1 in complex with the triazine inhibitor 2a (F219).

Summary for 6HOW

Entry DOI	10.2210/pdb6how/pdb
Related	6HNC 6HNR
Descriptor	Pteridine reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2~{R})-1-(3,4-dichlorophenyl)-2-(4-nitrophenyl)-2~{H}-1,3,5-triazine-4,6-diamine, ... (5 entities in total)
Functional Keywords	trypanosoma brucei, pteridine reductase, ptr1, tbptr1, triazine inhibitors, oxidoreductase
Biological source	Trypanosoma brucei brucei More
Total number of polymer chains	4
Total formula weight	126806.38
Authors	Landi, G.,Pozzi, C.,Mangani, S. (deposition date: 2018-09-18, release date: 2019-05-08, Last modification date: 2024-01-24)
Primary citation	Landi, G.,Linciano, P.,Borsari, C.,Bertolacini, C.P.,Moraes, C.B.,Cordeiro-da-Silva, A.,Gul, S.,Witt, G.,Kuzikov, M.,Costi, M.P.,Pozzi, C.,Mangani, S. Structural Insights into the Development of Cycloguanil Derivatives asTrypanosoma bruceiPteridine-Reductase-1 Inhibitors. Acs Infect Dis., 5:1105-1114, 2019 Cited by PubMed: 31012301 DOI: 10.1021/acsinfecdis.8b00358 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.92 Å)

Structure validation