6HMP
Crystal structure of human Casein Kinase I delta in complex with a photoswitchable 2-Azoimidazole-based Inhibitor (compound 3)
Summary for 6HMP
Entry DOI | 10.2210/pdb6hmp/pdb |
Descriptor | Casein kinase I isoform delta, 3-(2,5-dimethoxyphenyl)-~{N}-[4-[5-(4-fluorophenyl)-2-[(~{E})-(4-fluorophenyl)diazenyl]-3-methyl-imidazol-4-yl]pyridin-2-yl]propanamide, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | kinase, photoswitchable inhibitor, complex, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 74110.92 |
Authors | Pichlo, C.,Schehr, M.,Charl, J.,Brunstein, E.,Peifer, C.,Baumann, U. (deposition date: 2018-09-12, release date: 2019-09-11, Last modification date: 2024-01-24) |
Primary citation | Schehr, M.,Ianes, C.,Weisner, J.,Heintze, L.,Muller, M.P.,Pichlo, C.,Charl, J.,Brunstein, E.,Ewert, J.,Lehr, M.,Baumann, U.,Rauh, D.,Knippschild, U.,Peifer, C.,Herges, R. 2-Azo-, 2-diazocine-thiazols and 2-azo-imidazoles as photoswitchable kinase inhibitors: limitations and pitfalls of the photoswitchable inhibitor approach. Photochem. Photobiol. Sci., 18:1398-1407, 2019 Cited by PubMed: 30924488DOI: 10.1039/c9pp00010k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.039 Å) |
Structure validation
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