6HMO
Solution structure of the RNA duplex formed by the 5'-end of U1snRNA and the 5'-splice site of SMN2 exon7 in complex with the SMN-C5 splicing modifier
Summary for 6HMO
Entry DOI | 10.2210/pdb6hmo/pdb |
NMR Information | BMRB: 34312 |
Descriptor | RNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'), RNA (5'-R(*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3'), 2-(8-fluoranyl-2-methyl-imidazo[1,2-a]pyridin-6-yl)-7-(4-methylpiperazin-1-yl)pyrido[1,2-a]pyrimidin-4-one (3 entities in total) |
Functional Keywords | 5'-splice site bulge repair, u1 snrna, spinal muscular atrophy, bulge nucleotide, splicing modifier, rna |
Biological source | Homo sapiens More |
Total number of polymer chains | 2 |
Total formula weight | 7367.66 |
Authors | Campagne, S.,Allain, F.H. (deposition date: 2018-09-12, release date: 2019-08-14, Last modification date: 2024-05-15) |
Primary citation | Campagne, S.,Boigner, S.,Rudisser, S.,Moursy, A.,Gillioz, L.,Knorlein, A.,Hall, J.,Ratni, H.,Clery, A.,Allain, F.H. Structural basis of a small molecule targeting RNA for a specific splicing correction. Nat.Chem.Biol., 15:1191-1198, 2019 Cited by PubMed: 31636429DOI: 10.1038/s41589-019-0384-5 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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