6HMO

Solution structure of the RNA duplex formed by the 5'-end of U1snRNA and the 5'-splice site of SMN2 exon7 in complex with the SMN-C5 splicing modifier

6HMO の概要

• エントリーDOI: 10.2210/pdb6hmo/pdb
• NMR情報: BMRB: 34312
• 分子名称: RNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'), RNA (5'-R(*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3'), 2-(8-fluoranyl-2-methyl-imidazo[1,2-a]pyridin-6-yl)-7-(4-methylpiperazin-1-yl)pyrido[1,2-a]pyrimidin-4-one (3 entities in total)
• 機能のキーワード: 5'-splice site bulge repair, u1 snrna, spinal muscular atrophy, bulge nucleotide, splicing modifier, rna
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7367.66

構造登録者

Campagne, S.,Allain, F.H. (登録日: 2018-09-12, 公開日: 2019-08-14, 最終更新日: 2020-02-26)

• 主引用文献: Campagne, S.,Boigner, S.,Rudisser, S.,Moursy, A.,Gillioz, L.,Knorlein, A.,Hall, J.,Ratni, H.,Clery, A.,Allain, F.H.; Structural basis of a small molecule targeting RNA for a specific splicing correction.; Nat.Chem.Biol., 15:1191-1198, 2019; PubMed: 31636429; DOI: 10.1038/s41589-019-0384-5

実験手法

SOLUTION NMR