6HMB
STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA'; CSNK2A2 Gene product) IN COMPLEX WITH the inhibitor CX-4945 (Silmitasertib)
Summary for 6HMB
Entry DOI | 10.2210/pdb6hmb/pdb |
Related | 6HMC 6HMD 6HMQ |
Descriptor | Casein kinase II subunit alpha', 1,2-ETHANEDIOL, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | protein kinase ck2, casein kinase 2, catalytic subunit ck2alpha', csnk2a2, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 43921.22 |
Authors | Niefind, K.,Lindenblatt, D.,Applegate, V.M.,Jose, J.,Le Borgne, M. (deposition date: 2018-09-12, release date: 2019-03-27, Last modification date: 2024-05-15) |
Primary citation | Lindenblatt, D.,Nickelsen, A.,Applegate, V.M.,Hochscherf, J.,Witulski, B.,Bouaziz, Z.,Marminon, C.,Bretner, M.,Le Borgne, M.,Jose, J.,Niefind, K. Diacritic Binding of an Indenoindole Inhibitor by CK2 alpha Paralogs Explored by a Reliable Path to Atomic Resolution CK2 alpha ' Structures. Acs Omega, 4:5471-5478, 2019 Cited by PubMed: 31559376DOI: 10.1021/acsomega.8b03415 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.04 Å) |
Structure validation
Download full validation report