6HLP

Crystal structure of the Neurokinin 1 receptor in complex with the small molecule antagonist Netupitant

6HLP の概要

• エントリーDOI: 10.2210/pdb6hlp/pdb
• 分子名称: Substance-P receptor,Substance-P receptor, 2-[3,5-bis(trifluoromethyl)phenyl]-~{N},2-dimethyl-~{N}-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide, CITRIC ACID, ... (7 entities in total)
• 機能のキーワード: 7-tm; gpcr; signalling protein, membrane protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 67503.68

構造登録者

Schoppe, J.,Ehrenmann, J.,Klenk, C.,Rucktooa, P.,Schutz, M.,Dore, A.S.,Pluckthun, A. (登録日: 2018-09-11, 公開日: 2019-01-16, 最終更新日: 2024-01-24)

• 主引用文献: Schoppe, J.,Ehrenmann, J.,Klenk, C.,Rucktooa, P.,Schutz, M.,Dore, A.S.,Pluckthun, A.; Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists.; Nat Commun, 10:17-17, 2019; PubMed: 30604743; DOI: 10.1038/s41467-018-07939-8

実験手法

X-RAY DIFFRACTION (2.2 Å)