6HLO

Crystal structure of the Neurokinin 1 receptor in complex with the small molecule antagonist Aprepitant

Summary for 6HLO

Entry DOI	10.2210/pdb6hlo/pdb
Descriptor	Substance-P receptor,GlgA glycogen synthase,Substance-P receptor, 5-[[(2~{R},3~{S})-2-[(1~{R})-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one, CITRIC ACID, ... (6 entities in total)
Functional Keywords	7-tm; gpcr; signalling protein, membrane protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	65746.17
Authors	Schoppe, J.,Ehrenmann, J.,Klenk, C.,Rucktooa, P.,Schutz, M.,Dore, A.S.,Pluckthun, A. (deposition date: 2018-09-11, release date: 2019-01-16, Last modification date: 2024-01-24)
Primary citation	Schoppe, J.,Ehrenmann, J.,Klenk, C.,Rucktooa, P.,Schutz, M.,Dore, A.S.,Pluckthun, A. Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists. Nat Commun, 10:17-17, 2019 Cited by PubMed: 30604743 DOI: 10.1038/s41467-018-07939-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation