6HLO

Crystal structure of the Neurokinin 1 receptor in complex with the small molecule antagonist Aprepitant

6HLO の概要

• エントリーDOI: 10.2210/pdb6hlo/pdb
• 分子名称: Substance-P receptor,GlgA glycogen synthase,Substance-P receptor, 5-[[(2~{R},3~{S})-2-[(1~{R})-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one, CITRIC ACID, ... (6 entities in total)
• 機能のキーワード: 7-tm; gpcr; signalling protein, membrane protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 65746.17

構造登録者

Schoppe, J.,Ehrenmann, J.,Klenk, C.,Rucktooa, P.,Schutz, M.,Dore, A.S.,Pluckthun, A. (登録日: 2018-09-11, 公開日: 2019-01-16, 最終更新日: 2024-01-24)

• 主引用文献: Schoppe, J.,Ehrenmann, J.,Klenk, C.,Rucktooa, P.,Schutz, M.,Dore, A.S.,Pluckthun, A.; Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists.; Nat Commun, 10:17-17, 2019; PubMed: 30604743; DOI: 10.1038/s41467-018-07939-8

実験手法

X-RAY DIFFRACTION (2.4 Å)