6HKX
Eg5-inhibitor complex
Summary for 6HKX
Entry DOI | 10.2210/pdb6hkx/pdb |
Descriptor | Kinesin-like protein KIF11, ADENOSINE-5'-DIPHOSPHATE, (2~{S})-2-(3-azanylpropyl)-5-[2,5-bis(fluoranyl)phenyl]-~{N}-methoxy-~{N}-methyl-2-phenyl-1,3,4-thiadiazole-3-carboxamide, ... (6 entities in total) |
Functional Keywords | eg5, kif11, eg5-inhibitor, cell cycle |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 84067.37 |
Authors | Talapatra, S.K.,Kozielski, F. (deposition date: 2018-09-09, release date: 2019-09-25, Last modification date: 2024-01-17) |
Primary citation | Indorato, R.L.,Talapatra, S.K.,Lin, F.,Haider, S.,Mackay, S.P.,Kozielski, F.,Skoufias, D.A. Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5-Inhibitor Complexes. Mol.Cancer Ther., 18:2394-2406, 2019 Cited by PubMed: 31488701DOI: 10.1158/1535-7163.MCT-19-0154 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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