6HKX

Eg5-inhibitor complex

6HKX の概要

• エントリーDOI: 10.2210/pdb6hkx/pdb
• 分子名称: Kinesin-like protein KIF11, ADENOSINE-5'-DIPHOSPHATE, (2~{S})-2-(3-azanylpropyl)-5-[2,5-bis(fluoranyl)phenyl]-~{N}-methoxy-~{N}-methyl-2-phenyl-1,3,4-thiadiazole-3-carboxamide, ... (6 entities in total)
• 機能のキーワード: eg5, kif11, eg5-inhibitor, cell cycle
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 84067.37

構造登録者

Talapatra, S.K.,Kozielski, F. (登録日: 2018-09-09, 公開日: 2019-09-25, 最終更新日: 2024-01-17)

• 主引用文献: Indorato, R.L.,Talapatra, S.K.,Lin, F.,Haider, S.,Mackay, S.P.,Kozielski, F.,Skoufias, D.A.; Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5-Inhibitor Complexes.; Mol.Cancer Ther., 18:2394-2406, 2019; PubMed: 31488701; DOI: 10.1158/1535-7163.MCT-19-0154

実験手法

X-RAY DIFFRACTION (2.8 Å)