6HKQ
Human GPX4 in complex with covalent Inhibitor ML162 (S enantiomer)
Summary for 6HKQ
Entry DOI | 10.2210/pdb6hkq/pdb |
Related | 6HN3 |
Descriptor | Phospholipid hydroperoxide glutathione peroxidase, (2~{S})-2-[2-chloranylethanoyl-(3-chloranyl-4-methoxy-phenyl)amino]-~{N}-(2-phenylethyl)-2-thiophen-2-yl-ethanamide, SULFATE ION, ... (6 entities in total) |
Functional Keywords | anti-oxidatve defense system, covalent inhibitor, oxidoreductase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 21158.03 |
Authors | Hillig, R.C.,Moosmayer, D.,Hilpmann, A.,Hoffmann, L.,Schnirch, L.,Eaton, J.K.,Badock, V.,Gradl, S. (deposition date: 2018-09-07, release date: 2020-04-01, Last modification date: 2022-12-07) |
Primary citation | Moosmayer, D.,Hilpmann, A.,Hoffmann, J.,Schnirch, L.,Zimmermann, K.,Badock, V.,Furst, L.,Eaton, J.K.,Viswanathan, V.S.,Schreiber, S.L.,Gradl, S.,Hillig, R.C. Crystal structures of the selenoprotein glutathione peroxidase 4 in its apo form and in complex with the covalently bound inhibitor ML162. Acta Crystallogr D Struct Biol, 77:237-248, 2021 Cited by PubMed: 33559612DOI: 10.1107/S2059798320016125 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.54 Å) |
Structure validation
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