6HJT

The X-ray structure of the horse spleen ferritin nanocage containing Pt, obtained upon encapsulation of a Pt(II) terpyridine compound within the protein cage

Summary for 6HJT

• Entry DOI: 10.2210/pdb6hjt/pdb
• Descriptor: Ferritin light chain, CADMIUM ION, CHLORIDE ION, ... (8 entities in total)
• Functional Keywords: metal transport, metal-based compound encapsulation, ferritin nanocage, platinum based compound
• Biological source: Equus caballus
• Total number of polymer chains: 1
• Total formula weight: 22007.34

Authors

Pica, A.,Ferraro, G.,Merlino, A. (deposition date: 2018-09-04, release date: 2018-12-19, Last modification date: 2024-05-15)

Primary citation

Ferraro, G.,Pica, A.,Petruk, G.,Pane, F.,Amoresano, A.,Cilibrizzi, A.,Vilar, R.,Monti, D.M.,Merlino, A.
Preparation, structure, cytotoxicity and mechanism of action of ferritin-Pt(II) terpyridine compound nanocomposites.
Nanomedicine (Lond), 13:2995-3007, 2018

PubMed Abstract: A Pt(II)-terpyridine compound, bearing two piperidine substituents at positions 2 and 2' of the terpyridine ligand (1), is highly cytotoxic and shows a mechanism of action distinct from cisplatin. 1 has been incorporated within the ferritin nanocage (AFt).

PubMed: 30501559
DOI: 10.2217/nnm-2018-0259

Experimental method

X-RAY DIFFRACTION (1.33 Å)