6HID

The ATAD2 bromodomain in complex with compound 16

Summary for 6HID

• Entry DOI: 10.2210/pdb6hid/pdb
• Descriptor: ATPase family AAA domain-containing protein 2, SULFATE ION, ~{N}-[4-ethanoyl-5-(4-morpholin-4-ylcarbonylphenyl)-1,3-thiazol-2-yl]piperazine-2-carboxamide, ... (4 entities in total)
• Functional Keywords: bromodomain, atad2, inhibitor, complex, cytosolic protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 16436.61

Authors

Sledz, P.,Caflisch, A. (deposition date: 2018-08-29, release date: 2019-02-20, Last modification date: 2024-01-17)

• Primary citation: Dolbois, A.,Batiste, L.,Wiedmer, L.,Dong, J.,Brutsch, M.,Huang, D.,Deerain, N.M.,Spiliotopoulos, D.,Cheng-Sanchez, I.,Laul, E.,Nevado, C.,Sledz, P.,Caflisch, A.; Hitting a Moving Target: Simulation and Crystallography Study of ATAD2 Bromodomain Blockers.; Acs Med.Chem.Lett., 11:1573-1580, 2020; PubMed: 32832026; DOI: 10.1021/acsmedchemlett.0c00080

Experimental method

X-RAY DIFFRACTION (1.768 Å)