6HHF
Crystal Structure of AKT1 in Complex with Covalent-Allosteric AKT Inhibitor Borussertib
Summary for 6HHF
Entry DOI | 10.2210/pdb6hhf/pdb |
Descriptor | RAC-alpha serine/threonine-protein kinase, Borussertib (3 entities in total) |
Functional Keywords | akt1, borussertib, covalent-allosteric, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 52344.73 |
Authors | Landel, I.,Weisner, J.,Mueller, M.P.,Scheinpflug, R.,Rauh, D. (deposition date: 2018-08-28, release date: 2019-03-20, Last modification date: 2024-01-17) |
Primary citation | Weisner, J.,Landel, I.,Reintjes, C.,Uhlenbrock, N.,Trajkovic-Arsic, M.,Dienstbier, N.,Hardick, J.,Ladigan, S.,Lindemann, M.,Smith, S.,Quambusch, L.,Scheinpflug, R.,Depta, L.,Gontla, R.,Unger, A.,Muller, H.,Baumann, M.,Schultz-Fademrecht, C.,Gunther, G.,Maghnouj, A.,Muller, M.P.,Pohl, M.,Teschendorf, C.,Wolters, H.,Viebahn, R.,Tannapfel, A.,Uhl, W.,Hengstler, J.G.,Hahn, S.A.,Siveke, J.T.,Rauh, D. Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib inKRAS-Mutant Pancreatic and Colorectal Cancer. Cancer Res., 79:2367-2378, 2019 Cited by PubMed: 30858154DOI: 10.1158/0008-5472.CAN-18-2861 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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