6HGT
Crystal structure of human KDM4A complexed with co-substrate analog NOG and histone H3 peptide with K9R mutation
Summary for 6HGT
Entry DOI | 10.2210/pdb6hgt/pdb |
Descriptor | Lysine-specific demethylase 4A, Histone H3.3, ZINC ION, ... (5 entities in total) |
Functional Keywords | histone demethylase, inhibitor, transcription, oxidoreductase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 175009.48 |
Authors | Maw, J.,Le Bihan, Y.V.,van Montfort, R.L.M. (deposition date: 2018-08-23, release date: 2019-09-04, Last modification date: 2024-01-17) |
Primary citation | Maw, J.,Le Bihan, Y.V.,Bavetsias, V.,Blagg, J. Structure-based design of selective, histone substrate-based inhibitors of histone lysine demethylases 4 (KDM4) subfamily To be published, |
Experimental method | X-RAY DIFFRACTION (2.33 Å) |
Structure validation
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