6HGT

Crystal structure of human KDM4A complexed with co-substrate analog NOG and histone H3 peptide with K9R mutation

Summary for 6HGT

• Entry DOI: 10.2210/pdb6hgt/pdb
• Descriptor: Lysine-specific demethylase 4A, Histone H3.3, ZINC ION, ... (5 entities in total)
• Functional Keywords: histone demethylase, inhibitor, transcription, oxidoreductase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 175009.48

Authors

Maw, J.,Le Bihan, Y.V.,van Montfort, R.L.M. (deposition date: 2018-08-23, release date: 2019-09-04, Last modification date: 2024-01-17)

• Primary citation: Maw, J.,Le Bihan, Y.V.,Bavetsias, V.,Blagg, J.; Structure-based design of selective, histone substrate-based inhibitors of histone lysine demethylases 4 (KDM4) subfamily; To be published,

Experimental method

X-RAY DIFFRACTION (2.33 Å)