6HGT

Crystal structure of human KDM4A complexed with co-substrate analog NOG and histone H3 peptide with K9R mutation

6HGT の概要

• エントリーDOI: 10.2210/pdb6hgt/pdb
• 分子名称: Lysine-specific demethylase 4A, Histone H3.3, ZINC ION, ... (5 entities in total)
• 機能のキーワード: histone demethylase, inhibitor, transcription, oxidoreductase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 175009.48

構造登録者

Maw, J.,Le Bihan, Y.V.,van Montfort, R.L.M. (登録日: 2018-08-23, 公開日: 2019-09-04, 最終更新日: 2024-01-17)

• 主引用文献: Maw, J.,Le Bihan, Y.V.,Bavetsias, V.,Blagg, J.; Structure-based design of selective, histone substrate-based inhibitors of histone lysine demethylases 4 (KDM4) subfamily; To be published,

実験手法

X-RAY DIFFRACTION (2.33 Å)