6HGR

Crystal Structure of Human APRT wild type in complex with IMP

Summary for 6HGR

Entry DOI	10.2210/pdb6hgr/pdb
Related	6FCH 6FCI 6FCL 6FD4 6FD5 6FD6 6HGP 6HGQ
Descriptor	Adenine phosphoribosyltransferase, INOSINIC ACID (3 entities in total)
Functional Keywords	rossman fold, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	39551.32
Authors	Nioche, P.,Huyet, J.,Ozeir, M. (deposition date: 2018-08-23, release date: 2019-07-31, Last modification date: 2024-01-17)
Primary citation	Ozeir, M.,Huyet, J.,Burgevin, M.C.,Pinson, B.,Chesney, F.,Remy, J.M.,Siddiqi, A.R.,Lupoli, R.,Pinon, G.,Saint-Marc, C.,Gibert, J.F.,Morales, R.,Ceballos-Picot, I.,Barouki, R.,Daignan-Fornier, B.,Olivier-Bandini, A.,Auge, F.,Nioche, P. Structural basis for substrate selectivity and nucleophilic substitution mechanisms in human adenine phosphoribosyltransferase catalyzed reaction. J.Biol.Chem., 294:11980-11991, 2019 Cited by PubMed: 31160323 DOI: 10.1074/jbc.RA119.009087 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.52 Å)

Structure validation