6HG2

Hybrid dihydroorotase domain of human CAD with E. coli flexible loop, bound to fluoroorotate

6HG2 の概要

• エントリーDOI: 10.2210/pdb6hg2/pdb
• 分子名称: CAD protein, ZINC ION, 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, ... (5 entities in total)
• 機能のキーワード: de novo pyrimidine biosynthesis, cad, tim-barrel, carboxylated lysine, biosynthetic protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43202.82

構造登録者

Ramon-Maiques, S.,Del Cano-Ochoa, F. (登録日: 2018-08-22, 公開日: 2018-10-24, 最終更新日: 2024-01-17)

• 主引用文献: Del Cano-Ochoa, F.,Grande-Garcia, A.,Reverte-Lopez, M.,D'Abramo, M.,Ramon-Maiques, S.; Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD.; J. Biol. Chem., 293:18903-18913, 2018; PubMed: 30315107; DOI: 10.1074/jbc.RA118.005494

実験手法

X-RAY DIFFRACTION (1.83 Å)