6HEU
Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with the NVP-BHG712 derivative AT058
Summary for 6HEU
Entry DOI | 10.2210/pdb6heu/pdb |
Descriptor | Ephrin type-A receptor 2, 3-[(4,6-dipyridin-4-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{N}-[3-(trifluoromethyl)phenyl]benzamide (3 entities in total) |
Functional Keywords | inhibitor, complex, protein tyrosine kinase, transferase |
Biological source | Homo sapiens |
Total number of polymer chains | 1 |
Total formula weight | 34990.34 |
Authors | Kudlinzki, D.,Troester, A.,Witt, K.,Linhard, V.L.,Gande, S.L.,Saxena, K.,Schwalbe, H. (deposition date: 2018-08-20, release date: 2019-08-28, Last modification date: 2024-01-17) |
Primary citation | Troester, A.,Kudlinzki, D.,Saxena, K.,Gande, S.,Schwalbe, H. Effects of NVP-BHG712 chemical modifications on EPHA2 binding and affinity To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.719 Å) |
Structure validation
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