6HD6
ABL1 IN COMPLEX WITH COMPOUND6 AND IMATINIB (STI-571)
Summary for 6HD6
Entry DOI | 10.2210/pdb6hd6/pdb |
Related | 6HD4 |
Descriptor | Tyrosine-protein kinase ABL1, CHLORIDE ION, 3-(morpholin-4-ylmethyl)-~{N}-[4-(trifluoromethyloxy)phenyl]benzamide, ... (5 entities in total) |
Functional Keywords | phosphotransferase, inhibitor complex, transferase |
Biological source | Mus musculus (House Mouse) |
Total number of polymer chains | 2 |
Total formula weight | 68890.07 |
Authors | Cowan-Jacob, S.W. (deposition date: 2018-08-17, release date: 2018-09-12, Last modification date: 2024-05-15) |
Primary citation | Schoepfer, J.,Jahnke, W.,Berellini, G.,Buonamici, S.,Cotesta, S.,Cowan-Jacob, S.W.,Dodd, S.,Drueckes, P.,Fabbro, D.,Gabriel, T.,Groell, J.M.,Grotzfeld, R.M.,Hassan, A.Q.,Henry, C.,Iyer, V.,Jones, D.,Lombardo, F.,Loo, A.,Manley, P.W.,Pelle, X.,Rummel, G.,Salem, B.,Warmuth, M.,Wylie, A.A.,Zoller, T.,Marzinzik, A.L.,Furet, P. Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1. J. Med. Chem., 61:8120-8135, 2018 Cited by PubMed: 30137981DOI: 10.1021/acs.jmedchem.8b01040 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report