6HCZ

Sjoegren syndrome/scleroderma autoantigen 1 (SSSCA1)

6HCZ の概要

• エントリーDOI: 10.2210/pdb6hcz/pdb
• 分子名称: Sjoegren syndrome/scleroderma autoantigen 1, FORMIC ACID, ZINC ION, ... (4 entities in total)
• 機能のキーワード: sssca1, zinc binding, e3 ubiquitin ligase, intrinsically disordered protein (idp), wnt pathway, tankyrase binding, metal binding protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43169.48

構造登録者

Morth, J.P.,Perdreau-Dahl, H. (登録日: 2018-08-17, 公開日: 2020-03-18, 最終更新日: 2024-05-15)

主引用文献

Perdreau-Dahl, H.,Progida, C.,Barfeld, S.J.,Guldsten, H.,Thiede, B.,Arntzen, M.,Bakke, O.,Mills, I.G.,Krauss, S.,Morth, J.P.
Sjogren syndrome/scleroderma autoantigen 1 is a direct Tankyrase binding partner in cancer cells.
Commun Biol, 3:123-123, 2020

PubMed Abstract: Sjögren syndrome/scleroderma autoantigen 1 (SSSCA1) was first described as an auto-antigen over-expressed in Sjögren's syndrome and in scleroderma patients. SSSCA1 has been linked to mitosis and centromere association and as a potential marker candidate in diverse solid cancers. Here we characterize SSSCA1 for the first time, to our knowledge, at the molecular, structural and subcellular level. We have determined the crystal structure of a zinc finger fold, a zinc ribbon domain type 2 (ZNRD2), at 2.3 Å resolution. We show that the C-terminal domain serves a dual function as it both behaves as the interaction site to Tankyrase 1 (TNKS1) and as a nuclear export signal. We identify TNKS1 as a direct binding partner of SSSCA1, map the binding site to TNKS1 ankyrin repeat cluster 2 (ARC2) and thus define a new binding sequence. We experimentally verify and map a new nuclear export signal sequence in SSSCA1.

PubMed: 32170109
DOI: 10.1038/s42003-020-0851-2

実験手法

X-RAY DIFFRACTION (2.3 Å)