6HBN

HIGH-SALT STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA/CSKN2A1 GENE PRODUCT) IN COMPLEX WITH THE INDENOINDOLE-TYPE INHIBITOR THN27

6HBN の概要

• エントリーDOI: 10.2210/pdb6hbn/pdb
• 分子名称: Casein kinase II subunit alpha, CHLORIDE ION, 5-propan-2-yl-4-prop-2-enoxy-7,8-dihydro-6~{H}-indeno[1,2-b]indole-9,10-dione, ... (5 entities in total)
• 機能のキーワード: protein kinase ck2, casein kinase 2, catalytic subunit ck2alpha, csnk2a1, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 81227.78

構造登録者

Niefind, K.,Hochscherf, J.,Dimper, V.,Witulski, B.,Lindenblatt, D.,Jose, J.,Le Borgne, M. (登録日: 2018-08-10, 公開日: 2019-03-27, 最終更新日: 2024-01-17)

• 主引用文献: Lindenblatt, D.,Nickelsen, A.,Applegate, V.M.,Hochscherf, J.,Witulski, B.,Bouaziz, Z.,Marminon, C.,Bretner, M.,Le Borgne, M.,Jose, J.,Niefind, K.; Diacritic Binding of an Indenoindole Inhibitor by CK2 alpha Paralogs Explored by a Reliable Path to Atomic Resolution CK2 alpha ' Structures.; Acs Omega, 4:5471-5478, 2019; PubMed: 31559376; DOI: 10.1021/acsomega.8b03415

実験手法

X-RAY DIFFRACTION (1.59 Å)