6HAX

Crystal structure of PROTAC 2 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB

Summary for 6HAX

Entry DOI	10.2210/pdb6hax/pdb
Descriptor	Probable global transcription activator SNF2L2, von Hippel-Lindau disease tumor suppressor, Elongin-C, ... (8 entities in total)
Functional Keywords	bromodomain, e3 ubiquitin protein ligase, gene regulation
Biological source	Homo sapiens (Human) More
Total number of polymer chains	8
Total formula weight	114559.18
Authors	Roy, M.,Bader, G.,Diers, E.,Trainor, N.,Farnaby, W.,Ciulli, A. (deposition date: 2018-08-09, release date: 2019-06-12, Last modification date: 2024-01-17)
Primary citation	Farnaby, W.,Koegl, M.,Roy, M.J.,Whitworth, C.,Diers, E.,Trainor, N.,Zollman, D.,Steurer, S.,Karolyi-Oezguer, J.,Riedmueller, C.,Gmaschitz, T.,Wachter, J.,Dank, C.,Galant, M.,Sharps, B.,Rumpel, K.,Traxler, E.,Gerstberger, T.,Schnitzer, R.,Petermann, O.,Greb, P.,Weinstabl, H.,Bader, G.,Zoephel, A.,Weiss-Puxbaum, A.,Ehrenhofer-Wolfer, K.,Wohrle, S.,Boehmelt, G.,Rinnenthal, J.,Arnhof, H.,Wiechens, N.,Wu, M.Y.,Owen-Hughes, T.,Ettmayer, P.,Pearson, M.,McConnell, D.B.,Ciulli, A. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat.Chem.Biol., 15:672-680, 2019 Cited by PubMed: 31178587 DOI: 10.1038/s41589-019-0294-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation