6HA3

Human transketolase variant E160Q in covalent complex with donor ketose D-fructose-6-phosphate

Summary for 6HA3

Entry DOI	10.2210/pdb6ha3/pdb
Descriptor	Transketolase, 2-C-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium-2-yl}-6-O-phosphono-D-glucitol, 1,2-ETHANEDIOL, ... (7 entities in total)
Functional Keywords	thiamin diphosphate, tpp, thdp, enzyme, catalysis, sugar metabolism, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	71164.12
Authors	Dai, S.,Sautner, V.,Tittmann, K. (deposition date: 2018-08-07, release date: 2019-08-21, Last modification date: 2019-10-09)
Primary citation	Dai, S.,Funk, L.M.,von Pappenheim, F.R.,Sautner, V.,Paulikat, M.,Schroder, B.,Uranga, J.,Mata, R.A.,Tittmann, K. Low-barrier hydrogen bonds in enzyme cooperativity. Nature, 573:609-613, 2019 Cited by PubMed: 31534226 DOI: 10.1038/s41586-019-1581-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.08 Å)

Structure validation